Role of voltage-gated sodium channel modulators in peripheral nervous system disorders
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Date
2022-02Publisher
Brac UniversityAuthor
Mithila, Sabekun NaharMetadata
Show full item recordAbstract
In current therapy for controlling peripheral nervous system disorders, one of the milestones
is the voltage-gated sodium channel modulators. They have higher efficacy with improved
side effects. They target the channel and their different subunits to modify the nerve impulse
by allowing sodium ions. Selective drugs and biological products are used as modulators to
limit the negative effects of disorders. Some drugs may either activate or deactivate the
channels by altering the voltage-gated sodium channels pore. Moreover, biological products
like alkaloids, marine toxins have a crucial role in understanding binding sites with actions on
the sodium channel. Researchers are investigating numerous isoform-selective drugs in
treating peripheral nervous system-related disorders. In this report, detailed information about
the modulator's ongoing research on the active field is also elucidated.