A current insight into Aurora kinase inhibitors and their potential as anticancer agents
| bracu.degree.level | Undergraduate | |
| bracu.type.group | Student Works | |
| datacite.rights | Open Access | |
| dc.contributor.advisor | Khair, Nishat Zareen | |
| dc.contributor.author | Khushbu, Samia Sajnin | |
| dc.contributor.department | Department of Pharmacy | |
| dc.date.accessioned | 2024-10-01T03:57:03Z | |
| dc.date.available | 2024-10-01T03:57:03Z | |
| dc.date.copyright | ©2024 | |
| dc.date.issued | 2024-03 | |
| dc.description | Cataloged from PDF version of thesis. | |
| dc.description | Includes bibliographical references (pages 42-56). | |
| dc.description | This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. | en_US |
| dc.description.abstract | The Aurora kinases, comprising Aurora A, Aurora B, and Aurora C, constitute a family of serine/threonine protein kinases that plays a fundamental role in ensuring precise mitotic progression, regulating multiple phases of cell division, and maintaining genomic stability. The purpose of this review work is to provide an updated assessment of Aurora Kinase Inhibitors (AKIs) and their role as promising anticancer agents. Additionally, this article compiles the recent advancements in AKI research, encompassing novel compounds, their mechanisms of action, and preclinical/clinical trial outcomes. Aurora A regulates the process of maturation and separation of centrosomes, whereas Aurora B is responsible for ensuring precise chromosomal segregation. The significant correlation between the progression of malignancy and the dysregulation of Aurora kinases highlights their suitability as targets for pharmacological intervention, thereby making them a very promising area of emphasis for the creation of potent and specific anticancer drugs. | en_US |
| dc.description.degree | Bachelor of Pharmacy | |
| dc.description.statementofresponsibility | Samia Sajnin Khushbu | |
| dc.format.extent | 68 pages | |
| dc.identifier.other | ID 19346013 | |
| dc.identifier.uri | http://hdl.handle.net/10361/24255 | |
| dc.language.iso | en | en_US |
| dc.publisher | BRAC University | en_US |
| dc.rights | Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. | |
| dc.subject | Aurora kinases | en_US |
| dc.subject | Kinase inhibition | en_US |
| dc.subject | Small-molecule inhibitors | en_US |
| dc.subject | Anticancer agents | en_US |
| dc.subject.lcsh | Antineoplastic agents. | |
| dc.subject.lcsh | Cancer--Treatment. | |
| dc.subject.lcsh | Protein kinases--Inhibitors--Therapeutic use. | |
| dc.title | A current insight into Aurora kinase inhibitors and their potential as anticancer agents | en_US |
| dc.type | Thesis | en_US |