A current insight into Aurora kinase inhibitors and their potential as anticancer agents

Abstract

The Aurora kinases, comprising Aurora A, Aurora B, and Aurora C, constitute a family of serine/threonine protein kinases that plays a fundamental role in ensuring precise mitotic progression, regulating multiple phases of cell division, and maintaining genomic stability. The purpose of this review work is to provide an updated assessment of Aurora Kinase Inhibitors (AKIs) and their role as promising anticancer agents. Additionally, this article compiles the recent advancements in AKI research, encompassing novel compounds, their mechanisms of action, and preclinical/clinical trial outcomes. Aurora A regulates the process of maturation and separation of centrosomes, whereas Aurora B is responsible for ensuring precise chromosomal segregation. The significant correlation between the progression of malignancy and the dysregulation of Aurora kinases highlights their suitability as targets for pharmacological intervention, thereby making them a very promising area of emphasis for the creation of potent and specific anticancer drugs.