In-vitro antioxidant and cytotoxicity screening of ethanolic extract of lagerstroemia thorelli (Lythraceae) leaves

Abstract

"Substantial antioxidant activity of Lagerstroemia thorelli leaves extract was revealed in DPPH free radical scavenging assay with an IC50 value of 83.05085 μg/mL compared to that of 47.55245 μg/mL demonstrated by ascorbic acid. Besides, the total phenolic content test exhibited concentration of phenolic compounds in the extract to be 122.6309 mg/g GAE of dry extract. Afterwards, cytotoxicity of the extract was assessed in terms of LC50 value. During the brine shrimp lethality bioassay, cytotoxicity of the leaf extract was evaluated to be impotent based on the LC50 at 28861.40 μg/mL against that of 0.000145 μg/mL for vincristine sulfate. However, more advanced researches must be performed to discover other pharmacological properties of L. thorelli. Conclusively, on the basis of the present preliminary study, it can be claimed that the profound antioxidant property can be utilized to treat many oxidative stress-associated diseases."