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    • Bachelor of Pharmacy
    • Project report (Bachelor of Pharmacy)
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    Development of dissolution medium of poorly soluble drug by using surfactants

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    11146001.pdf (1.401Mb)
    Date
    2015-08
    Publisher
    BRAC Univeristy
    Author
    Shoaib, Syed Hasan Mahamud
    Metadata
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    URI
    http://hdl.handle.net/10361/9140
    Abstract
    The drug dissolution from its dosage form is considered as an important parameter in the absorption. Drugs which are fairly soluble in gastrointestinal (GI) media exhibit complete oral absorption leading to better bioavailability. For BCS class II drug, solubility is a crucial rate limiting factor to achieve its desired level in systemic circulation for pharmacological response. In this review article, study shown to improve the drug solubility by adding surfactant into the dissolution media. Especially we have found the solubility data on the drugs having low solubility like Glipizide, Carvedilol, Carbamazepine, Mefenamic acid, Simvaststin, Candesartan Cilexetil and Ibuprofen. For the improvement of their dissolution medium surfactants like SLS, Tween 80, SDS are being used. For Glipizide, Carvedilol, pure Carbamazepine, CBZ–NIC co crystal and the physical mixtures of CBZ III and NIC, Simvastatin, Mefenamic acid, Ibuprofen and Candesartan Cilexetil the highest solubility was found in the medium containing 0.75% SLS in phosphate buffer pH 6.8, 3% SLS in water and 3% SLS in 0.1 N HCL, 10.4 mM SLS in water, 0.1% SLS in water, 2% w/v of SLS, 0.1% SDS in phosphate buffer pH 7.2 and 0.35% w/v Tween 20 in phosphate buffer pH 6.5 respectively.
    Keywords
    British pharmacopeia; Drug; Carbamazepine
     
    Description
    This project report is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2015.
     
    Cataloged from PDF version of project report.
     
    Includes bibliographical references (page 60-64).
    Department
    Department of Pharmacy, BRAC University
    Type
    Project report
    Collections
    • Project report (Bachelor of Pharmacy)

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