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    Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

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    Date
    2014
    Publisher
    © 2014 BioMed Central Ltd.
    Author
    Sorowar Hossain, Mohammad
    Iqbal, Mohd S
    Ahmed Khan, Mohiuddin
    Golam Rabbani, Mohammad
    Khatun, Hazera
    Munira, Sirajam
    Miah, M Morshed Zaman
    Kabir, Amin Lutful
    Islam, Naima
    Farhana Dipta, Tashmim
    Rahman, Farzana
    Mottalib, Abdul
    Afrose, Salma
    Ara, Tasneem
    Biswas, Akhil Ranjan
    Rahman, Mizanur
    Abedin, AKM Mustafa
    Rahman, Mahbubur
    Yunus, ABM
    Niessen, Louis W
    Sultana, Tanvira Afroze
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/7566
    Citation
    Hossain, M. S., Iqbal, M. S., Khan, M. A., Rabbani, M. G., Khatun, H., Munira, S., . . . Sultana, T. A. (2014). Diagnosed hematological malignancies in bangladesh - A retrospective analysis of over 5000 cases from 10 specialized hospitals. BMC Cancer, 14(1) doi:10.1186/1471-2407-14-438
    Abstract
    Background: The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh.Methods: This was a multi-center hospital-based retrospective descriptive study of over 5000 confirmed hematological cancer cases in between January 2008 to December 2012. Morphological typing was carried out using the " French American British" classification system.Results: A total of 5013 patients aged between 2 to 90 years had been diagnosed with malignant hematological disorders. A 69.2% were males (n = 3468) and 30.8% females (n = 1545), with a male to female ratio of 2.2:1. The overall median age at diagnosis was 42 years. Acute myeloid leukemia was most frequent (28.3%) with a median age of 35 years, followed by chronic myeloid leukemia with 18.2% (median age 40 years), non-Hodgkin lymphoma (16.9%; median age 48 years), acute lymphoblastic leukemia (14.1%; median age 27 years), multiple myeloma (10.5%; median age 55 years), myelodysplastic syndromes (4.5%; median age 57 years) and Hodgkin's lymphoma (3.9%; median age 36 years). The least common was chronic lymphocytic leukemia (3.7%; median age 60 years). Below the age of 20 years, acute lymphoblastic leukemia was predominant (37.3%), followed by acute myeloid leukemia (34%). Chronic lymphocytic leukemia and multiple myeloma had mostly occurred among older patients, aged 50-over.Conclusions: For the first time, our study presents the pattern and distribution of diagnosed hematological cancers in Bangladesh. It shows differences in population distributions as compared to other settings with possibly a lower presence of non-Hodgkin lymphoma. There might be under-reporting of affected women. Further studies are necessary on the epidemiology, genetics and potential environmental risk factors within this rapidly aging country.
    Keywords
    ALL; AML; Bangladesh; CML; Hematological malignancy; HL; MDS; MM; NHL
     
    Description
    This article was published in BMC Cancer [© 2014 BioMed Central Ltd.] and the definite version is available at: http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-438
    Publisher Link
    http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-438
    DOI
    http://doi.org/10.1186/1471-2407-14-438
    Department
    James P Grant School of Public Health, BRAC University
    Type
    Article
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