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dc.contributor.authorHossain, M.S.
dc.contributor.authorAlam, M.B.
dc.contributor.authorChowdhury, N.S.
dc.contributor.authorAsadujjaman, M.
dc.contributor.authorZahan, R.
dc.contributor.authorIslam, M.M.
dc.contributor.authorMazumder, M.E.H.
dc.contributor.authorHaque, M.E.
dc.contributor.authorIslam, A.
dc.identifier.citationHossain, M. S., Alam, M. B., Chowdhury, N. S., Asadujjaman, M., Zahan, R., Islam, M. M., . . . Islam, A. (2011). Antioxidant, analgesic and anti-inflammatory activities of the herb eclipta prostrate. Journal of Pharmacology and Toxicology, 6(5), 468-480. doi:10.3923/jpt.2011.468.480en_US
dc.descriptionThis article was published in Journal of Pharmacology and Toxicology [© 2011 Academic Journals Inc.] and the definite version is available at:
dc.description.abstractThe present study was designed to investigate the antioxidant, analgesic and anti-inflammatory potential of the methanolic extract along with its organic soluble fractions of the herb Eclipta prostrata. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Antioxidant potential of the extract/fractions was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl), NO (nitric oxide) and ONOO- (peroxynitrite) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC50 value of 12.98±0.08, 45.98±0.07 and 14.45±0.18 μg mL-1 for DPPH, NO and ONOO- assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their analgesic (hot plate, tail immersion and acetic acid induced writhing test) and anti-inflammatory (carrageenan induced paw edema in rats) activities at a dose level of 200 and 400 mg kg-1 body weight. Among all the extract/fractions, EtOAc fraction showed a dose dependent and significant (p<0.005, p<0.05) analgesic activity in all the tested method. EtOAc fractions also reduced the paw edema considerably (86.80% inhibition after 3 h, p<0.005, p<0.05) in dose dependent manner compared to carrageenan induced rat. Altogether, these results suggest that the MeOH extract and its organic soluble fractions could be used as a potential antioxidant, analgesic and anti-inflammatory agenten_US
dc.publisher© 2011 Academic Journals Inc.en_US
dc.subjectEclipta prostrataen_US
dc.subjectFree radicalen_US
dc.titleAntioxidant, analgesic and anti-inflammatory activities of the herb Eclipta Prostrateen_US
dc.contributor.departmentDepartment of Pharmacy, BRAC University

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