Show simple item record

dc.contributor.authorMosharraf, Fahareen-Binta-
dc.contributor.authorAhsan, Chowdhury Rafiqul
dc.contributor.authorYasmin, Mahmuda
dc.contributor.authorNessa, Jamalun
dc.identifier.citationMosharraf, F.-B., Ahsan, C. R., Yasmin, M., & Nessa, J. (2015). An appraisal of bacteriophages as biocontrol agent in treating E.coli O157:H7 mediated experimental gastroenteritis in mice. International Journal of Multidisciplinary Research and Development, 2(4), 606–614. Retrieved from
dc.descriptionThis article was published in the International Journal of Multidisciplinary Research and Development [© 2015] and The Journal's website is at:
dc.description.abstractThe emergence of new pathogenic bacteria resistant to most, if not all, currently existing antimicrobial agents has become a serious problem in modern medicine, particularly because of the affiliated increase in immunosuppressed inhabitants worldwide. The recent surfacing of E. coli O157:H7 as a foremost food pathogen is a lively reminder of its dynamic character. Mounting concerns about drug-resistant pathogenic bacteria have rekindled interest in alternative treatments of bacterial infections. Prominent among these alternatives is phage therapy for combating supportive infections. This observation particularly calls for the in vivo examination of environmental phage candidates to treat stx1A and stx2A positive Escherichia coli O157:H7 induced experimental diarrhea. Two O157-specific lytic bacteriophages PAH6 and P2BH2 were isolated from sewage and characterized. Healthy conventional Swiss albino mice were used for investigating the O157:H7 specific diarrhea applied through three alternative routes (oral, intramuscular and intraperitoneal).The highest titer of orally added E. coli 0157:H7 was found to be fatal within 24 hrs. A single oral dose of phage strain (1X107 PFUml-1) alone or in combination was sufficient to rescue 100% of the animals from this lethal challenge in vivo. Finally, the results obtained in this study suggest that cocktail of two coliphages applied orally for treatment gastrointestinal infection have good therapeutic potential.en_US
dc.publisher© 2015 International Journal of Multidisciplinary Research and Developmenten_US
dc.subjectEscherichia coli O157:H7 infectionen_US
dc.subjectStreptomycin treated murine modelen_US
dc.subjectPhage therapen_US
dc.titleAn appraisal of bacteriophages as biocontrol agent in treating E.coli O157:H7 mediated experimental gastroenteritis in miceen_US
dc.contributor.departmentDepartment of Mathematical and Natural Science, BRAC University

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record