Comparison and evaluation of aceclofenac nanoemulsion formulation using homogenization and ultrasonication techniques
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Date
2020-02Publisher
Brac UniversityAuthor
Jahan Saiky, Kazi MustariMetadata
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The goal of this study is to evaluate aceclofenac nanoemulsion formulations with varying
surfactant-co-surfactant ratio and method of preparation. Aceclofenac is a BCS class II NSAID,
with greater anti-inflammatory action than traditional NSAIDS. Ten formulations were prepared
in this study, using aceclofenac as the active pharmaceutical ingredient. All 10 formulations
contained same amount of aceclofenac, which was 1.5%. Percentage of all the other reagents
were kept constant as well except for Tween-80 and ethanol (surfactant and co-surfactant). F1,
F2, F3, F4 and F5 were formulated through homogenization method, whereas F1´, F2´, F3´, F4´
and F5´ were formulated through ultrasonication method. All 10 formulations remained stable
after 14 days. To further evaluate the formulations, studies like dye test, dilution test,
conductivity test, fluorescence test was done. The techniques successfully resulted in 10 stable
emulsions, but more studies, e.g. droplet size analysis, zeta potential test, percent transmittance,
in-vitro analysis can further confirm if the formulations are nanoemulsions.