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dc.contributor.advisorTalukder, Mesbah
dc.contributor.authorHossain, Ragib
dc.date.accessioned2024-06-05T06:08:23Z
dc.date.available2024-06-05T06:08:23Z
dc.date.copyright©2023
dc.date.issued2023-02
dc.identifier.otherID 19146002
dc.identifier.urihttp://hdl.handle.net/10361/23148
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.en_US
dc.descriptionCataloged from the PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 24-28).
dc.description.abstractInfections caused by fungi typically affect the skin, nails, and lungs but they can also penetrate the skin, infect the organs and spread throughout the body but research has found that dermatophytosis of the toenails and fingernails, known as onychomycosis, is more challenging to treat with medication than fungal infections of other body parts. Due to their high cure rates and safety profiles, azole antifungals replaced topical treatments in treating onychomycosis. However, studies suggest these medicines cause Hepatotoxicity and Acute kidney injury. In this study information from the FAERS database is analyzed using a reporting odds ratio (ROR) to identify potential danger signs. Hepatotoxicity Reporting odds ratio for drug's were, Voriconazole 8.16 (6.29, 10.60) > Itraconazole 3.98 (1.99, 7.96) > Posaconazole 3.23 (1.62, 6.47). Additionally, Acute kidney Injury Reporting odds ratio for selected drug were, Voriconazole 0.46 (0.33, 0.65) > Posaconazole 0.37 (0.19, 0.71) > Itraconazole 0.10 (0.03, 0.40).en_US
dc.description.statementofresponsibilityRagib Hossain
dc.format.extent40 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectOnychomycosisen_US
dc.subjectHepatotoxicity
dc.subjectAcute Kidney Injury
dc.subject.lcshOnychomycosis
dc.subject.lcshHepatotoxicology
dc.subject.lcshAcute renal failure
dc.titleHepatotoxicity and acute kidney injury associations with itraconazole, voriconazole and posaconazole in the treatment of Onychomycosis: pharmacovigilance study of FDA adverse event reporting system data (FAERS)en_US
dc.typeThesisen_US
dc.contributor.departmentSchool of Pharmacy, Brac University
dc.description.degreeB. Pharmacy


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