dc.contributor.advisor | Talukder, Mesbah | |
dc.contributor.author | Afroza, Halima | |
dc.date.accessioned | 2024-01-09T04:08:56Z | |
dc.date.available | 2024-01-09T04:08:56Z | |
dc.date.copyright | 2023 | |
dc.date.issued | 2023-02 | |
dc.identifier.other | ID 19146018 | |
dc.identifier.uri | http://hdl.handle.net/10361/22075 | |
dc.description | This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. | en_US |
dc.description | Cataloged from PDF version of thesis. | |
dc.description | Includes bibliographical references (pages 21-25). | |
dc.description.abstract | The objective of this study was to investigate the association between TNF-alpha inhibitors and alopecia cases in psoriasis patients reported in the Food and Drug Administration Adverse Event Reporting System (FAERS) database. We performed a disproportionality analysis (case/non-case method) to examine the relationship between the development of alopecia by the use of TNF-alpha inhibitors from January 2016 to September 2022. Cases were all alopecia reports, whereas non-cases were all the other reports reported throughout the research period. We calculated the reported odds ratio (ROR) and corresponding 95% confidence interval (CI) to assess disproportionality signals and determine the relationship between alopecia and TNF-alpha inhibitors. As a positive control, docetaxel was used. Our study found that only infliximab and certolizumab pegol showed signal for alopecia. Additional study into alopecia connected with TNF-alpha inhibitors usage in psoriasis patients is required as disproportionality signals may have been altered by stimulated reporting or nocebo effect. | en_US |
dc.description.statementofresponsibility | Halima Afroza | |
dc.format.extent | 25 pages | |
dc.language.iso | en | en_US |
dc.publisher | Brac University | en_US |
dc.rights | Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. | |
dc.subject | Psoriasis | en_US |
dc.subject | Alopecia | en_US |
dc.subject | TNF-α inhibitor | en_US |
dc.subject | FAERS | en_US |
dc.subject | ROR | en_US |
dc.subject | Disproportionality analysis | en_US |
dc.title | TNF-α inhibitor-induced alopecia in psoriatic disease patients: a pharmacovigilance study | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | School of Pharmacy, Brac University | |
dc.description.degree | B. Pharmacy | |