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    •   BracU IR
    • School of Pharmacy (PHR)
    • Bachelor of Pharmacy
    • Project report (Bachelor of Pharmacy)
    • View Item
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    Recent advances in Cancer treatment targeting autophagy and future aspects

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    18146020_PHR.pdf (488.8Kb)
    Date
    2022-03
    Publisher
    Brac University
    Author
    Emon, Kamrul Hasan
    Metadata
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    URI
    http://hdl.handle.net/10361/17247
    Abstract
    Lysosomal autophagy controls cellular homeostasis by degrading and recycling cytoplasmic molecules and organelles in the lysosome. This process in neuronal cells protects cognitive decline by removing abnormal intracellular protein accumulation. Since autophagy is well-known, new regulators of the process are expected to be discovered. It has been hypothesized that modulating autophagy can be employed as a therapeutic mechanism to boost the efficacy of traditional medicines, such as chemotherapy and radiation therapy. Thus, a critical concern in cancer therapy is whether to promote or inhibit autophagy. To enable the successful development of treatments targeting autophagy, a complete knowledge of the molecular components of autophagy is addressed here, with a particular emphasis on druggable targets, combination therapy are also explored as well as the possible hurdles and constraints for the application of these innovative therapeutic techniques in clinical practice.
    Keywords
    Autophagy; Autophagic cell death; Anticancer therapy; Chemotherapy; Autophagy inhibitors
     
    LC Subject Headings
    Cell death; Lysosomes; Cancer--Treatment
     
    Description
    This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
     
    Cataloged from PDF version of thesis report.
     
    Includes bibliographical references (pages 31-55).
    Department
    Department of Pharmacy, Brac University
    Collections
    • Project report (Bachelor of Pharmacy)

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