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Optimization of transpeptidation reaction of the insulin precursor for efficient yield recovery during downstream processing
(BRAC University, 2017)
Nowadays Yeast cell is a popular host for recombinant human insulin production where initially it secrets insulin precursor fusion protein with N-terminal spacer peptide and deletedthreonineB30, followed by a small C-peptide ...
Investigation of insulin promoter factor 1 gene C18R and R197H variants association with type 2 diabetes mellitus in Bangladeshi population
(Brac University, 2019-07)
Diabetes Mellitus (DM) is a common metabolic disorder, resulting from defects in insulin secretion,
insulin action, or both. But the molecular mechanism behind the basic defects of DM is not yet fully
understood. Defect ...