Analgesic and CNS depressant activities of methanolic shell extract of Nypa fruticans Wurmb fruit in Swiss albino mice

Abstract

The study explored the analgesic and CNS depressant activities of a methanolic shell extract from Nypa fruticans Wurmb fruit. Methanolic shell extract of N. fruticans Wurmb fruit was acetic acid induced technique was used to test the analgesic efficacy in mice. An evaluation of CNS depressant activity used the hole cross test. Different doses (200, 400, and 600 mg/kg) were administered to mice, and results indicated significant dose-dependent analgesic and CNS depressant activities (p<0.05). The extract exhibited enhanced analgesic effects, achieving 51.16% inhibition at 600 mg/kg, whereas the standard drug Indomethacin achieved 79.54% inhibition. At 600 mg/kg, the extract reduced locomotor activity and exploratory behavior, similar to standard drug diazepam. These findings highlighted the notable analgesic and CNS depressant activities of the methanolic shell extract from N. fruticans Wurmb fruit.