In vivo studies of analgesic, antidiabetic, and CNS depressant properties of Pterocarpus indicus leaf extract

Abstract

The species Pterocarpus indicus belongs to the Fabaceae family, locally known as Padauk. Plants belonging to this family can treat rheumatic pain, insomnia, stress, and an increased heartbeat. However, through a literature search, it was seen no one has investigated the analgesic, antidiabetic, and CNS depressant properties of the ethanol leaf extract of P. indicus. This research aimed to investigate therapeutic properties like analgesic, antidiabetic, and CNS depressants of Pterocarpus indicus leaf extract using Swiss albino mice at doses of 200 mg/kg, 400 mg/kg, and 600 mg/kg. The antidiabetic effect was evaluated on alloxan-induced diabetic mice, the acetic acid-induced writhing test was used for the analgesic activity, and the hole cross method was employed for the CNS depressant effect. The extract showed significant anti diabetic activity (P<0.01), notable analgesic and CNS depressant effects. Hence, the findings suggest that the extract of Pterocarpus indicus could be effective in diabetes treatment.