A review on relationship of SNP at rs2228570 of VDR gene and different diseases in different populations

Abstract

Multiple disorders are caused by mutations in the vitamin D receptor (VDR) gene. The VDR gene directs the body to manufacture vitamin D receptor protein (VDR). This vitamin D receptor is engaged in vitamin D-mediated reactions. This vitamin D level is one of the most important prognostic markers for several disorders. It is believed that several disorders are related to VDR gene polymorphism. Scientists are also interested in leprosy, osteoporosis, osteoarthritis, parkinson, breast cancer, and diabetes in an effort to better understand the impact of variation in the VDR gene in disease development in different populations. Additionally, many studies have associated vitamin D with enhanced immunological function. Consequently, this polymorphism may contribute to the emergence of the above-mentioned disorders. This study proposed that a particular nucleotide polymorphism (SNP) at rs2228570 site of the VDR gene is associated with different diseases.