Pharmacological investigations of methanolic extract of Mangifera indica peels

Abstract

Mangifera indica has many traditional uses int reating various diseases which has been scientifically proven by its antioxidant,immunomodulatory,anti-inflammatory,anti-allergic,anti-diabetic,antiviral,antibacterial,anti-fungal and monoamine-oxidase inhibitory effects.In this report powdered Mangifera indica peelwas extracted with methanol which was further screened for phytochemical analysis.Phytochemical screening revealed the presence of flavonoid, saponins, tannins, steroids, terpenoids, glycosides, alkaloids and carbohydrates in the peels of Mangifera indica. In the screening of hypoglycemic activity, Glibenclamide was used as a standard drug at a dose of 10mg/kg and methanolic extract of Mangifera indica was used a study sample. Methanolic crude extract at a dose of 200mg/kg and 400mg/kg showed moderate blood glucose lowering activity of 66.06% and 54.88% respectively after 90 minutes of oral administration of glucose.Methanolic extract was also evaluated for cytotoxic activity following brine shrimp cytotoxicity bioassay where Vincristine sulfate was used as standard and the study samples showed LC50 of 2.04 μg/ml.