Biomarkers of Alzheimer’s disease: a hope for early diagnosis

Abstract

Alzheimer’s disease is a complex neurodegenerative disease which requires very specific biomarkers for its diagnosis. This review is mainly focused on finding out the biomarkers that are currently used to diagnose Alzheimer’s Disease. Biomarkers are the biological markers and help to reveal what is going on inside the brain due to Alzheimer’s Disease. Thus, the biomarkers become the most important factors in early diagnosis of the disease. The literature review revealed that in most of the cases, the target biomarkers are CSF amyloid-β and -protein aggregates, although only the -protein is very specific to Alzheimer’s disease in comparison with any other forms of dementia. However, there are also other types of biomarkers currently being used like blood and ocular biomarkers. In the conclusion it can be inferred that, this review will help to identify the biomarkers which needs to be established for the better diagnosis and management of Alzheimer’s disease.