Trastuzumab & Pertuzumab in the fight against breast cancer: mechanisms, significance, & future aspects

Abstract

Cancer is a dangerous disease that has plagued humanity for centuries, ranking asathe second leadingacauseaofaglobal mortality. Ina2020, nearly 20 million lives were lost to cancer, with breast cancer (BC) being the most common type. Understanding the risk factors for developing BC, such as family history, is crucial for improving survival rates. There are various treatment methods available for BC, including the use of docetaxel with monoclonal antibodies Pertuzumab & Trastuzumab, which target the overexpressed the human epidermal growth factor receptor 2 (HER2) gene in HER2-positive breast tumors. These antibodies have significantly changed the therapeutic strategy for the human epidermal growth factor receptor 2(HER2)- positive breast cancer. However, while patient results have improved, the number of people benefiting from this medication. This paper aims to explore all available BC treatments & propose a model of the synergistic effects of trastuzumab & pertuzumab, critically analyzing findings & hypotheses related to their combined activity.