The role of SIRT6 in down regulation of colorectal cancer

Abstract

This work is based on SIRT6 role in down regulation of colorectal cancer. Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide+ (NAD+) dependent enzyme and stress response protein which can play an important role in tumorigenesis. In this paper, the relation between SIRT6 and colorectal cancer has been discussed. For this purpose, STRING and KEGG pathway were used. The link between SIRT6 and 204 different proteins were determined and the confidence score was calculated using STRING. From this study, key proteins for colorectal cancer were identified using KEGG pathway. The study showed that MYC, PTEN, PI3K and mTOR were the therapeutic targets for SIRT6. Moreover, SIRT6 inhibits PI3K/Akt signaling pathway and thus inhibits cancer cell proliferation. It also inhibits mTOR signaling pathway resulting in cancer cell apoptosis. Thus, the current study proposes that upregulating the expression of SIRT6 can be used as a therapeutic tool in combatting colorectal cancer.