Possible treatments of Huntington’s disease: a comprehensive review

Abstract

Huntington's disease (HD) is characterized by chorea, cognitive impairment, and behavioral problems; it is a hereditary, progressive neurological condition. HD is becoming easier to diagnose and learn about, but it is still tricky to treat due to severe symptoms and a lack of authorized therapeutic approaches. Both non pharmacologic and pharmacologic approaches have been studied, with more than 80 medicines from different classes having been the subject of clinical trials or case reports. However, antidopaminergic drugs are typically only used to treat motor dysfunction while antidepressants are used to treat mood problems, leaving cognitive impairment untreated. Clinical trials have focused on multiple potential mechanisms for altering symptoms and disease progression.