Heat shock protein: potential approach for chemotherapy

Abstract

Overexpression of heat shock proteins occurs in a variety of malignancies in humans. It has also been linked to tumor cell invasion and immune system detection. Several Hsp have also been linked to the prognosis of particular cancers. Hsp70 and Hsp90 expression, for example, Hsp is said to be associated with a worsening prognosis in SCC, breast, bladder, and other cancers. This review article focuses on a collection of medications that have been utilized in cancer clinical trials, as well as the process' approach and outcomes. In addition, the center of attention of this article is the modifying Hsp expression or chaperone activity with pharmaceutical agents, as well as the utilization of Hsps as immunological adjuvants in anticancer vaccines. Furthermore, the applications of software and the future of heat shock protein have been examined.