Exploring the role of programmed cell death protein 1 in alzheimer’s disease associated autoimmunity

Abstract

Alzheimer’s disease is the most common type of neurodegenerative disorder oriented dementia which is regulated by chronic inflammation in brain cells. Nevertheless, repeated experiments with immunosuppressive agents had failures to treat AD, implementing immune checkpoint blockade to affect the pathogenesis of AD showed some lights of hope in animal model. These animal trials stated about the mitigation of neuronal inflammatory responses and diminution in amyloid beta plaque formation and decrease in Tau protein entanglement. The cognitive symptoms were also observed as falling down. A massive surprising change in the tau pathology was informed by these researches that the macrophages were increased within neuronal parenchyma. In general, almost all the relevant experiments stated that PD-1 and ligand targeted immune checkpoint blockade can modify the factors which help to progress AD or cognitive behaviors. So this pathway can help to combat this disease succefully.