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Investigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extract

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bracu.degree.levelUndergraduate
bracu.type.groupStudent Works
datacite.rightsOpen Access
dc.contributor.advisorAkter, Raushanara
dc.contributor.authorKhan, Mujtaba Ali
dc.contributor.departmentDepartment of Pharmacy
dc.date.accessioned2020-08-11T12:36:19Z
dc.date.available2020-08-11T12:36:19Z
dc.date.copyright2019
dc.date.issued2019-10
dc.descriptionCataloged from PDF version of thesis report.
dc.descriptionIncludes bibliographical references (pages 69-89).
dc.descriptionThis thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2019.en_US
dc.description.abstractBlumea lacera (family: Asteraceae) is a very potent plant for its various therapeutic properties. This research was intended to detect the antioxidant and cytotoxic potential of chloroform extract of this plant leaf. Antioxidant potential was assessed by a number of in-vitro antioxidant studies and among them DPPH free radical scavenging assay showed 86.43% inhibition of free radicals at 1200μg/mL of the extract with IC50 of 2.39μg/mL. Highest total phenolic content (TPC), total flavonoid content (TFC) and total antioxidant capacity (TAC) was found to be 285.47mg of GAE/g, 287.12mg of QE/g and 272.21mg of AAE/g at 1200μg/mL of extract, respectively. Cytotoxic activity was measured using in-vitro MTT assay against HeLa and MOLT-4 cell lines that showed IC50 of 3.46mg/mL and 3.29mg/mL for the extract. These results showed that the extract had strong antioxidant and low cytotoxic potential.en_US
dc.description.degreeBachelor of Pharmacy
dc.description.statementofresponsibilityMujtaba Ali Khan
dc.description.statementofresponsibilityMujtaba Ali Khan
dc.format.extent89 pages
dc.identifier.otherID 15346039
dc.identifier.urihttp://hdl.handle.net/10361/13939
dc.language.isoenen_US
dc.publisherBRAC Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectAntioxidanten_US
dc.subjectCytotoxicen_US
dc.subjectFree radicalen_US
dc.subjectPhenolicen_US
dc.subjectFlavonoiden_US
dc.subject.lcshMedicinal plants
dc.subject.lcshMateria medica, Vegetable
dc.titleInvestigation of in-vitro antioxidant and cytotoxic activity of Blumea lacera leaf extracten_US
dc.typeThesisen_US

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