Progress of finding latent therapeutic activity of vaccine for Alzheimer’s disease

Abstract

Alzheimer’s disease is one of leading diseases which provokes different internal physiological conditions that ease deterioration of normal body mechanism among people over 60 years of age. The proper pathophysiology of this disease is still undiscovered. There are two neuropathological hallmarks for this deadliest disease, among them one is amyloid-β and another is senile plaque deposition which plays extracellular role, on the other side neurofibrillary tangles which contain hyperphosphorylated tau protein dominate intracellular portion. A variety of medicinal approaches have been experimented targeting amyloid-β among them the most innovative approaches were reducing amyloid-β from the brain by active and passive vaccination. Since the first approach, a number of vaccines have been stopped during clinical trials and some are still under investigation. Different co-relating possibilities are merging together to initiate a proper medicinal pathway along with the invention of the specific pathophysiology of this disease.