Therapeutic implication of senescent cell elimination in neurodegenerative diseases

Abstract

Neurodegenerative disease is a condition where the function of the brain gets affected due to neuronal death. Still, there is no proper way to cure this disease, but there are some drugs and treatments that can reduce the side effects caused by this disease. Senescent cell elimination is a treatment used to treat neurodegenerative diseases like Alzheimer’s disease (AD), Parkinson’s disease (PD), etc. It has been revealed that senescent cell causes impaired learning, memory loss, etc. Excess production of amyloid precursor protein and amyloid-β (Aβ) also cause impaired learning or memory loss problems, so senescent cells contribute to neurodegenerative diseases. So, eliminating senescent cells is an excellent method or treatment for neurodegenerative diseases. Senolytic drugs are one kind of senescent cell elimination treatment that induces apoptosis in senescent cells, and senostatics is another senescent cell elimination treatment that blocks or stops the proliferation of senescence.