Prospective detection methods for Tau protein: an important biomarker for Alzheimer’s disease

Abstract

Tau protein is one of the keystones in the diagnosis of Alzheimer’s disease. The modern detection techniques have come up to visualize, track and assess tau pathology and have further contributed with information about tau deposition in human brain. The commercially available techniques include PET scan, digitalized enzyme-linked immunosorbent assay, Biolayer interferometry. However, each of the techniques has its own limitations such as tracers binding to off target, higher chances of cross reaction. This report has detailed the information about the active field of ongoing research methods to detect tau protein such as Surface plasmon resonance, Quartz crystal microbalance, Surface-enhanced Raman scattering based sandwich assay along with their selectivity. Hence, all of these techniques can be used to detect the inhibitors that target tau protein deposits or phosphorylates.