Application of microRNA (miRNA) in Alzheimer’s Disease (AD)

Abstract

Alzheimer's disease is a fatal illness that primarily affects older generations; its pathology pathways include beta-amyloid, tau protein, and activated microglia, destruction of synapse and no disease-modifying medication has been found. MicroRNA has the potential to be a novel therapeutic method by targeting certain mRNAs that cause the disease to worsen, so their overexpression causes a reduction in disease, and another class of microRNA targets those mRNAs that are required for a healthy brain, but their overexpression causes the disease to worsen. There are several microRNAs, and each one has a different target and impact in the brain, with some having a therapeutic effect and others having a pathogenic effect. MicroRNA is a promising therapeutic agent and drug target which needs to be implemented in human trials, not just animal models.