An review of alkylating-like agents in reducing mortality of cancer patients: structure & synthesis

Abstract

Cancer is known as one of the world’s deadliest diseases characterized by uncontrolled cellular proliferation. Alkylating agents are one class of anticancer drugs which cross-link DNA strands and induce cell death. The ultimate objective of alkylating agents is to enhance patient outcomes and lessen the impact of cancer on society. In this review article, a thorough overview of alkylating agents utilized in cancer treatment is covered. It will discuss mechanism of actions, structure-activity relationships (SARs), synthesis, and potential future direction of alkylating agents. Specifically, alkylating agents that are historically important, currently used or seem promising in clinical trials are mainly discussed here. The objective of the review is expected to aid pharmacologists, synthetic and medicinal chemists and other healthcare professionals who are working in the field of antineoplastic drugs to provide a state-of-the-art knowledge in making these drugs, mechanisms of actions and its synthetic procedures in the literature.