A comprehensive review on investigations of chronic neuropsychological impact of SARS-COV-2

Abstract

This review aims to provide a comprehensive knowledge on various long-term neuropsychological consequences of SARS-CoV-2. There are numerous pieces of evidence indicating that neuropsychological symptoms might continue long after the disease has ended. This study synthesizes findings from a wide range of studies conducted worldwide and provides a thorough evaluation of research on the chronic neuropsychological impact of SARS-CoV-2. A total of 54 studies were included in the review. There were various types of studies including retrospective study, cross-sectional study, prospective study, case study, investigational study, survey study, observational study and longitudinal study. This review investigates the multidimensional nature of neuropsychological problems reported in people recovering from COVID-19 shedding information on cognitive deficits, attention problem, psychiatric issues, memory problem, olfactory disorder, anxiety, depression, insomnia, and neurological consequences that persist even after acute respiratory symptoms have subsided. This comprehensive review adds to our growing understanding of the long-term effects of COVID-19 on the human brain by applying a wide range of tools and methods on the participants including PHQ-9, MMSE, MoCA, GAD-7, PCL-5, PSS-10, Brief-COPE, BRB-NT, IES-R, FSS, COMPASS-31, FAS etc. It emphasizes not only the current state of knowledge, but also the need for ongoing research to inform effective therapeutic interventions, rehabilitation strategies, and preventive measures to reduce the long-term neuropsychological burden on people recovering from SARS-CoV-2 infection.