Targeting circular RNA for cardiovascular diseases

Abstract

Circular RNAs (CircRNAs) are ubiquitous, and covalently closed loop structures. They are single-stranded molecules without free 3′ and 5 ′ ends. CircRNAs have been rapidly gaining momentum as a potential therapy option for a wide range of cardiovascular disorders, including coronary artery disease (CAD), Cerebrovascular disease (CVD), Peripheral artery disease (PAD), and Aortic atherosclerosis. This review explores several critical aspects such as circRNA biogenesis and suggested biogenesis models, circRNA detection and validation methods, circRNA functions, and current therapeutic uses of circRNA technology. To increase efficacy, these advancements are being researched both independently and in combination with other technologies as well. Significant advances may pave the road for circular RNA technology to be successful in treating these diseases, which are currently affecting a big part of the human population.