A review on antimicrobial resistance and emerging strategies to tackle it

Abstract

Global health concerns are now significantly attributed to the emergence of antimicrobial treatment resistance. When antibiotics were initially developed in the early 1920s, many people believed that disease had finally been defeated by humans. However, it soon became clear that any antibiotic utilized might not be effective against the bacteria. Almost all pathogenic bacteria appear to be capable of developing resistance to various antibiotic classes. By deepening our knowledge on how the resistance develops, we would be able to maximize the available drug therapy as well as develop novel antimicrobial agents. This review will address epidemiology of antimicrobial resistance, resistance mechanism, existing therapies, recent advancements in this field along with challenges and limitations to counter antimicrobial resistance.