Effects of Allium sativum extract in arsenic induced toxicity in Swiss albino mice

Abstract

Arsenic (As) is metal toxic element to the body and it is available in environment. Arsenicosis, elevated level of As in body, can be treated by chelation therapy. In chelation therapy, a chelate is used to form a complex chemical structure with the metal ion. As, Allium sativumis a natural chelate and this study focuses on the in vivo evaluation of the chelating effect of Allium sativum(methanolic extract) of different doses (150, 300, 500 mg/kg) on the depletion of arsenic from the cellular level, using Swiss albino mice. Body weight, hematological and biochemical parameters like, WBC, RBC, NEU, ALP, CRE, cellular structure of skin, brain, kidney, liver were observed and significant amount of changes were found. Allium sativa, popularly known as the garlic, is an influential antioxidant that, have the potential to detox the body via its chelating characteristics by absorbing toxic substances or metal sections.