Self-micro emulsifying drug delivery system: An approach to improve the solubility of Itraconazole

Abstract

The study is designed to improve the bioavailability of Itraconazole by developing a self-micro emulsifying drug delivery system (SMEDDS). A series of SMEDDS were prepared with different ratios of oil, surfactant and co-surfactant and examined for emulsification. Pseudo ternary phase diagram was used to find out the optimized concentration of the components. The dissolution profile of the optimized SMEDDS-ITZ was performed in aqueous media. The physicochemical characteristic of SMEDDS-ITZ were also examined by dynamic light scattering (DLS). The possible interaction between the components were checked by Fourier Transform Infrared spectroscopy (FT-IR). The results from the dissolution study of the prepared formulation suggests that the SMEDDS can be promising approach for Itraconazole and other Biopharmaceutics Classification System (BCS) Class II drugs to reduce dosing frequency and to improve the bioavailability.