Cryo-EM in COVID-19 drug invention and discovery

Abstract

Cryo-EM is a type of electron microscope that employs the cryomicroscopy technology, which involves cooling materials and examining them under a microscope to create 3D models of proteins. Throughout this COVID-19 pandemic, the development of medicines are critical, and the protein structures of the SARS-CoV-2 virus must be recognized in order to battle COVID 19. Cryo-EM may be used to find protein structural alignments, protein positioning, domain motif interaction with known antiviral medications, and potential therapeutic routes for creating treatments and vaccines. Furthermore, because Cryo-EM allows scientists to examine dynamic models of proteins, it makes it simpler for them to analyze molecules of various shapes and dimensions, which may be a significant benefit over X-ray crystallography. The use of Cryo-EM in medication development for COVID-19 including how future drugs can be designed to counter COVID-19 are discussed in this review paper so that the pandemic can be brought to a close.