A study of Osteosarcoma gene profile

Abstract

Osteosarcoma is a type of bone cancer casting huge threat to the human health worldwide. It is a primary bone malignancy with a particularly high incidence rate in children and adolescents relative to other age groups. The etiology of this often aggressive cancer is currently unknown, because complicated structural and numeric genomic rearrangements in cancer cells preclude understanding of tumour development. The aim of the study is to analyze gene expression to identify biomarkers for osteosarcoma. We downloaded and mined two expression profile datasets associated with osteosarcoma from the Gene Expression Omnibus. After data background correction we analyzed the data using R studio software. However, we could not achieve our cherished result due to some package error in the software. Though we could not figure out the possible biomarkers using our data but some studies has been found that gene which take part in antigen presentation and immune process are highly expressed in the escalation of osteosarcoma cell growth the expression genes in all were shown as heatmap. Doing further study of osteosarcoma cell growth, it may help to facilitate the individual management of patients with osteosarcoma after treatment.