Role of voltage-gated sodium channel modulators in peripheral nervous system disorders

Abstract

In current therapy for controlling peripheral nervous system disorders, one of the milestones is the voltage-gated sodium channel modulators. They have higher efficacy with improved side effects. They target the channel and their different subunits to modify the nerve impulse by allowing sodium ions. Selective drugs and biological products are used as modulators to limit the negative effects of disorders. Some drugs may either activate or deactivate the channels by altering the voltage-gated sodium channels pore. Moreover, biological products like alkaloids, marine toxins have a crucial role in understanding binding sites with actions on the sodium channel. Researchers are investigating numerous isoform-selective drugs in treating peripheral nervous system-related disorders. In this report, detailed information about the modulator's ongoing research on the active field is also elucidated.