Anti-inflammatory effect of Statins in reducing the exacerbation and mortality rates of COPD patients: a review study

Abstract

Statins are cholesterol lowering drugs used against obesity in relation to hypertension and cardiovascular diseases, across the world, in an extensive scale. It reduces the synthesis of cholesterol by inhibiting the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) used in the mevalonate pathway. However recent studies have reflected their pleiotropic effect on victims of chronic obstructive pulmonary disease (COPD). In addition, to provide the cholesterol lowering action they have also shown an anti –inflammatory effect on the affected patients. Since the most commonly used treatment procedures are not successful in limiting the increasing cases of exacerbation and mortality rates of COPDs, use of statins will offer a new way out for the physicians. Different authentic papers, journals regarding this issue have been searched and their results have been compiled. Majority papers showed positive result which provides a positive effect of statin in COPD patient.