A review of Isotretinoin and its association in affective disorder

Abstract

Isotretinoin is a medication used in the treatment of severe to moderate acne. However, several studies have reported a potential association between Isotretinoin use and affective disorders (depression, anxiety, suicidal ideation). In the review, an attempt is made to understand how the use of Isotretinoin is associated with affective disorder. Several published materials reporting psychiatric side effects following Isotretinoin treatment including case reports were being studied for this review. Some studies have proposed a possible connection between Isotretinoin usage and affective disorders where retinoic acid plays a crucial role. Retinoic acid may cross the blood-brain barrier so it can have an effect on CNS which may lead to affective disorder. However, no causal relationship has not been established and the link between Isotretinoin use and psychiatric events remains controversial. Because of the lack of evidence, broad research is needed to understand the relationship between Isotretinoin and mental health outcomes.