Significance of using Poloxamer 407 and Lactose in ibuprofen in vitro solubility enhancement

Abstract

Ibuprofen is a widely used NSAID drugs dealing with mild to moderate pain formulated in numerous dosage forms. But ibuprofen has very poor solubility in water associated with minimal drug absorption hence leading to infrequent and low bioavailability. The following project was taken to determine the solubility profile of the drug in presence of poloxamer 407 and L- lactose as excipients since dissolution of orally taken dosage form principally depends on the solubility. While using poloxamer 407, ibuprofen solubility increases in presence of both co-solvents water and ethanol (in 10%and 20%). On the other hand, while using lactose, ibuprofen shows increased solubility profile in water. But even though ibuprofen has better solubility in ethanol, using lactose in 10% and 20% ethanol for ibuprofen did not show any significant solubility profile that may because of inadequate solubility of lactose in ethanol leads to super saturation of ethanol by lactose.