A review on antitubercular drugs: mechanism of actions, resistance, SARs & synthesis

Abstract

Mycobacterium tuberculosis (M.tb) is considered the second leading cause of death after COVID-19. The rate of mortality and morbidity is increasing day by day due to its resistance to drugs. People in developing countries tend to ignore the symptoms of tuberculosis which leads to not taking proper treatments and more transmission. Researchers from different countries are focusing on the discovery and development of anti-tubercular drugs. The main focus is to eradicate tuberculosis completely from the world through a specific therapy. Ensuring early diagnosis and appropriate treatment can help stop the transmission of M.tb. This paper reviews the comprehensive details regarding the diagnoses and treatments of M.tb as well as the mechanism of actions and synthetic strategies of current anti-tubercular drugs. This review focusses on both convention and latest information so that it can help researchers to know and understand about the tuberculosis and aid development of new anti-tubercular drugs.