Restless Legs Syndrome: a review from causation to cure

Abstract

Restless legs Syndrome (RLS) is a common neurological disorder which manifests as an urge to move the legs when at rest. The disease is often misdiagnosed due to its low recognition and patient’s difficulty to explain their symptoms. The exact mechanism in which the disease develops is still unknown and the pathogenesis is based on different hypothesis. A universal treatment plan for this disease is also unknown and every patient needs individualized treatment depending on their condition. Different conditions have been proved to be associated with this disease such as, Iron Deficiency Anemia, Diabetes Mellitus and End Stage Renal Disease. This review article emphasizes on the pathogenesis of the disease based on different hypothesis. It also establishes connection between this disease and other conditions. Lastly, it provides individualized treatment plans for each category of patients based on evidence.