Evaluation of the safety and efficacy of oral isotretinoin in the treatment of acne

Abstract

Acne is a prevalent skin disorder. Isotretinoin is an FDA-approved retinoic acid isomer frequently used to cure or remission this obstinate condition when other procurable approaches and antibiotics fail. However, the oral form is reportedly responsible for some unusual side effects in some patients. This systematic review is intended to summarize the findings regarding safety, efficacy and any observed side effects throughout the oral Isotretinoin treatment. Data about acne pathogenesis, epidemiology and mechanism of action of Isotretinoin was also synthesized. According to the tabular representation of information, it can be considered that incident of side effects and adverse drug reaction occurrence is typically dose-dependent and sometimes reversible with some specific precautions. Severe adverse incidents such as teratogenicity are quite uncommon and can be avoided by adhering to safety regulations or using contraception. However, considering the negligible occurrence of adverse events and adequate patient satisfaction, isotretinoin can be an economical and efficient choice for the First-line treatment for acne treatment and reduce the use of oral or topical antibiotics in this antibiotic resistance awareness era.