The impact of cell penetrating peptides in prospective cancer therapy: a review

Abstract

Cell penetrating peptides have been identified as a viable tool for therapeutic use in the era of biomedicines and specialized carrier systems. Similar to other therapeutic peptides, peptide stability- the bottleneck for this class of biodegradable molecules will play a critical role in the effective in vivo deployment of CPPs. Peptide-based administration could improve drug uptake in tumor cells, increasing the effectiveness of either conventional small-molecule medications or oligonucleotide-based treatments. To facilitate the achievement of therapeutic interventions, a thorough understanding of the cancer applications of cell penetrating peptides as delivery systems is stressed; including various aspects of drug loading, cargoes, and delivery are discussed along with techniques for targeted delivery, activatable cell-penetrating peptides, and transducible agents coupled to cell-penetrating peptides. Limitations and possible solutions invented are also mentioned.