Screening of analgesic activity of flacourtia jangomes flesh on swiss albino mice.

Abstract

Flucortia jangomes is a wild fruit species founded in hill tracks of Bangladesh. This is a less explored plant but carries many phytochemical constituents and has a variety of pharmacological activities. This study investigated central and peripheral analgesic activity of methanolic extracts of F. jangomes flesh on Swiss Albino mice. After extraction two main methods were used here – tail immersion method and acetic acid induced writhing method. Three different doses 100 mg/kg, 200mg/kg and 300mg/kg were administered to mice. A dose dependent activity was observed during the experiments and noticeable analgesic effects were seen. Statistical analysis of values indicates ** p < 0.01 and * p < 0.05 vs. Control and 60.01% inhibition was observed at 300 mg/kg dose. However, standard solution shows higher (72.78%) percent inhibition that the extract solution. The result of experiments show potential analgesic activity of F. jangomes fruit flesh and further studies are needed to identify the active phytochemical constituents which is responsible for this anti-nociceptive activity.