A review on adult neurogenesis in Alzheimer’s disease

Abstract

In the adult brain, neurogenesis is the process through which neural stem cells mainly generate new neurons. Adult neurogenesis occurs in two regions of the CNS such as, the subventricular zone and the subgranular zone of the hippocampal dentate gyrus. Alzheimer's disease is an age-related, gradual and chronic neurodegenerative disease which can cause huge neuronal death and decrease cognitive function. Moreover, the patients with Alzheimer's disease mainly develop exceptional atrophy in entorhinal cortex in the process of adult hippocampal neurogenesis and the dentate gyrus constantly generating new granule neurons. There is a relation between AD and adult neurogenesis, and the differences in the field are also discussed here. In this review, I tried to present the therapeutic importance of promoting neurogenesis which is applicable to stop or treat cognitive deficiencies connected to neurodegenerative diseases and aging.