Solid self-emulsifying drug delivery system of domperidone for improved biopharmaceutical characteristics

Abstract

The aim of this study was to use a solid-self emulsifying drug delivery system (S-SEDDS) to increase the solubility and dissolution rate of Domperidone (DMP), a poorly soluble, weakly basic anti-emetic medication. Several ratios of Kollisolv, Kolliphor® P188, and Glycerin were trialed and an S-SEDDS-DMP was formulated using the optimized ratio. Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-ray Powder Diffraction (XRPD), Fourier-transform infrared spectroscopy (FT-IR), and in-vitro dissolution rate experiments were used to characterize the S-SEDDS-DMP. The lack of incompatibilities between DMP and the utilized polymers was established by FT-IR and DSC tests. DSC, SEM, and XRPD analyses demonstrated that the drug in the produced S-SEDDS changed from crystalline to amorphous. It may be stated that the S-SEDDS approach was a successful tool for improving DMP dissolution.