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Targeted therapeutic options in the treatment of Breast Cancer

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bracu.degree.levelUndergraduate
bracu.type.groupStudent Works
datacite.rightsOpen Access
dc.contributor.advisorKabir, Dr. Eva Rahman
dc.contributor.authorAlam, Kazi Tasnuva
dc.contributor.departmentDepartment of Pharmacy
dc.date.accessioned2022-11-15T03:55:22Z
dc.date.available2022-11-15T03:55:22Z
dc.date.copyright2022
dc.date.issued2022-02
dc.descriptionCataloged from PDF version of thesis report.
dc.descriptionIncludes bibliographical references (pages 35-48).
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.en_US
dc.description.abstractThe recent application of targeted therapies such as biologics, biosimilars, and other targeted biological agents in the treatment of diverse subtypes of breast cancer has been facilitated by the decoding of the human genome and the subdivision of breast cancer on a molecular level. This review focuses on targeted therapeutic approaches used in breast cancer therapy, such as anti-HER2 targeted monoclonal antibodies, CDK4/6 inhibitors, immune checkpoint inhibitors, blockers of the PI3K/AKT/mTOR signaling pathways, PARP inhibitors, Antibody-Drug Conjugates (ADCs), and anti-VEGF agents. Moreover, this paper specifically discusses the role of trastuzumab in the treatment of HER2-positive breast tumors, as well as its approved biosimilars which aim to make breast cancer treatment affordable, while preventing cancer recurrence and improving overall therapeutic efficacyen_US
dc.description.degreeBachelor of Pharmacy
dc.description.statementofresponsibilityKazi Tasnuva Alam
dc.format.extent48 Pages
dc.identifier.otherID: 18146028
dc.identifier.urihttp://hdl.handle.net/10361/17562
dc.language.isoen_USen_US
dc.publisherBRAC Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectBreast canceren_US
dc.subjectTargeted therapyen_US
dc.subjectBiologicsen_US
dc.subjectBiosimilarsen_US
dc.subjectHER2en_US
dc.subjectTrastuzumaben_US
dc.subject.lcshBreast--Cancer--Patients
dc.subject.lcshBreast--Cancer--Treatment
dc.titleTargeted therapeutic options in the treatment of Breast Canceren_US
dc.typeThesisen_US

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Project report & Thesis (Bachelor of Pharmacy)