SIRT6 and cancer stem cells: is there any implication?

Abstract

Cancer resembles a genetic disease that develops due to the uncontrollable growth of cells in the host body. The most prominent cause of this fatal disease development is the presence of cancer stem cells (CSCs) arise either from normal progeny or present in cancer cells which trigger cancer progression eventually metastasis due to the influence of over-expressive cell surface markers, mutated transcription factors, and dysregulated signaling pathways, etc. Besides, this progression is also modulated by an epigenetic enzyme known as SIRT6 which is closely associated with the cancer stem cells and functionally involved in cancer regulation due to its dichotomous nature. This project paper highlights the implication between cancer stem cells and Sirtuin 6 (SIRT6) in cancer progression as well as suppression along with a demonstration of the activity of several pharmacological modulators on SIRT6 in cancer regulation for the implementation of personalized medicines that can eradicate this fatal disease.