A review on the therapeutic design and challenges of potential COVID-19 vaccines

Abstract

An unprecedented emerge of a rapid human-to-human transmissible respiratory illness, known as COVID-19 caused by the SARS-CoV-2, a novel coronavirus from December 2019, in Wuhan, China has changed the world drastically. Soon after its emergence the virus caused a serious health emergency that compelled the health officials to declare it an epidemic, followed by a global pandemic by the World Health Organization (WHO). In spite of some drug’s improving results for treating the symptoms of COVID-19, it has been however recommended that only an effective vaccine can help get rid of this pandemic. In response to this pandemic an unbelievable effort has been observed to develop a vaccine due to the strong coordination and cooperation among the stakeholders, funders, vaccine developers, regulatory authorities, policy makers, governments etc. In this review the ongoing strategies for developing COVID-19 vaccines, some vaccine candidates and their pre- and post-development challenges have been comparatively analyzed.